Computational system biology

All biology is computational biology

Here, I argue that computational thinking and techniques are so central to the quest of understanding life that today all biology is computational biology. Computational biology brings order into our understanding of life, it makes biological concepts rigorous and testable, and it provides a reference map that holds together individual insights. The next modern synthesis in biology will be driv...

Computational Biology

A pair in a string is the occurrence of the same substring twice. A pair is maximal if the two occurrences of the substring cannot be extended to the left and right without making them different. The gap of a pair is the number of characters between the two occurrences of the substring. In this paper we present methods for finding all maximal pairs under various constraints on the gap. In a str...

Computational Biology

2. Computational Genomics and Proteomics . . . . . . . . . . . . . . . . 3 2.1. DNA Sequencing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.2. DNA and RNA Structures . . . . . . . . . . . . . . . . . . . . . . 3 2.3. Protein Sequencing . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.4. Protein Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.5. ...

Quantitative stem cell biology: computational studies in the hematopoietic system.

PURPOSE OF REVIEW This review is intended to provide an overview of recently published computational methods, including bioinformatic algorithms, mathematical models and simulation studies, applied to stem cell biology, with particular reference to the hematopoietic system. RECENT FINDINGS The analysis of molecular data is making an increased contribution to identify dynamic system responses....

Computational Molecular Biology